Is it possible to prevent chronic graft-versus-host disease?

 

A procedure termed an allogeneic stem cell transplant can deliver the most wished-for outcome in cancer treatment: a cure, for certain patients with severe blood malignancies like certain forms of leukemia.

However, graft-versus-host disease, a long-term, devastating disorder, can occur as a result of the treatment (GVHD). When immune cells from the donor are supplied together with stem cells during transplantation, they target healthy tissues in the recipient's body as well as cancer cells, resulting in GVHD.

A recent study suggests that eliminating immunecells known as naïve T cells from donor cells before transplantation may be a technique to avoid persistent GVHD after a stem cell transplant. The researchers discovered that this significantly lowered the probability of chronic GVHD in study participants while having no effect on their chances of recurrence.

Blood malignancies are caused by stem cells in the bone marrow, which create all of the body's blood cells, including the white blood cells that fight infections. People with some severe kinds of blood cancer may need an allogeneic stem cell transplant as part of their treatment.

High doses of chemotherapy and, in certain cases, radiation treatment are used to destroy the bone marrow, which is where the stem cells reside. The patient is then given an infusion of healthy stem cells from a matched donor, usually a family member, to reduce the chances of transplant rejection and GVHD.

Immunosuppressive medications can have negative side effects and increase the risk of infection. They can also be problematic if cancer recurs. People on these medicines can't get immunotherapies like CAR T cells, but they also can't quit taking them without their GVHD getting worse.

Comments

Post a Comment

Popular posts from this blog

Can Eating Burnt Foods Causes Cancer?

Image
  Overcooking items including toast, roast potatoes, chips, and vegetables, according to health experts, can cause cancer . According to the Food Standards Agency, starchy foods cooked at high temperatures for too long produce acrylamide, a carcinogenic chemical. When starchy foods are cooked at high temperatures, a chemical substance called acrylamide forms. A chemical interaction between specific carbohydrates and an amino acid (asparagine) in the diet causes it to develop. When muscle meat, such as beef, pig, fish, or chicken, is cooked at high temperatures, such as pan frying or grilling directly over an open flame, compounds called heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs) are generated. HCAs and PAHs have been discovered to be mutagenic in laboratory trials, meaning they create changes in DNA that may raise the risk of cancer. When amino acids, carbohydrates, and creatine or creatinine (muscle-derived compounds) react at high temperatures, H...
Read more

Is HPV 56 associated with a high risk of Cancer?

Image
  HPV 56 is a human papilloma from hybridization and partial nucleotide sequence analysis, the structure of HPV-56's open reading frames was determined, revealing a typical HPV genome. HPV-56 was found in two out of every 464 normal cervical tissues, five out of every 227 cervical condylomas and CIN, and two out of every 84 invasive cervical malignancies. HPV types 16, 18, 31, 33, 34, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68, and 70 are high-risk. Some HPV varieties that are less commonly identified in malignancies but are regularly seen in squamous intraepithelial lesions are included in the high-risk group. More than 30 different kinds of human papillomavirus (HPV) infect the vaginal region. There is a well-established link between certain oncogenic (high-risk) HPV strains and cervical cancer. Although HPV is required for cervical epithelial cell transformation, it is not sufficient, and a number of cofactors and molecular processes have a role in whether cervical cancer devel...
Read more