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Mitochondrial linkage of Cancer

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It has long been considered that the glycolysis is the major metabolic process that drives aberrant cancercell proliferation , suggesting that the impaired mitochondrial function  may be the underlying cause of cancer. These findings have eventually eradicated the major misconception that cancer is a purely cell-intrinsic disorder that stems from epigenetic or genetic alterations . Although the mitochondrial defect for cancer invasiveness is long known but its relation to treatment resistance remained unclear. Recently, from the studies of aggressive breastcancer cells, scientists have found that the movement of mitochondria inside the cell is being controlled by the pathway- called Arf6-AMP1-PRKD2 . It is known that the mitochondria generally move inside the cells under various circumstances but in cancer cells, it congregates in the leading rim of the cell. It is due to the pathway- Arf6-AMP1-PRKD2, which helps to recycle the protein, named integrin in the cancerous cells which th
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Is it possible to prevent chronic graft-versus-host disease?

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  A procedure termed an allogeneic stem cell transplant can deliver the most wished-for outcome in cancer treatment: a cure, for certain patients with severe blood malignancies like certain forms of leukemia. However, graft-versus-host disease , a long-term, devastating disorder, can occur as a result of the treatment (GVHD). When immune cells from the donor are supplied together with stem cells during transplantation, they target healthy tissues in the recipient's body as well as cancer cells, resulting in GVHD. A recent study suggests that eliminating immunecells known as naïve T cells from donor cells before transplantation may be a technique to avoid persistent GVHD after a stem cell transplant. The researchers discovered that this significantly lowered the probability of chronic GVHD in study participants while having no effect on their chances of recurrence. Blood malignancies are caused by stem cells in the bone marrow, which create all of the body's blood cells,
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Can chemo cause internal bleeding?

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Your bone marrow makes cells known as platelets . These cells keep you from hurt an excessive amount of by serving to your grume. Therapy, radiation, and bone marrow transplants will destroy a number of your platelets. This could result in hurt throughout cancer treatment. However, large higher GI hurt is typically a sickness 1st presentation or treatment associated complication throughout therapy (and not four weeks once chemotherapy). Therapy will cause an individual to bruise or bleed additional simply. Many of us having therapy expertise this aspect impact. Hurt additional heavily than usual is dangerous. Low living substance counts may result from therapy. If you notice uncommon hurt, as well as blood in your body waste, stool, vomit, or hurt gums, give notice your doctor. Easier bruising or longer hurt time once a minor cut is traditional. Red blood cells may be laid low with some therapy medication. Most sorts of pain associated with therapy recover or escape between treatmen
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Is HPV 56 associated with a high risk of Cancer?

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  HPV 56 is a human papilloma from hybridization and partial nucleotide sequence analysis, the structure of HPV-56's open reading frames was determined, revealing a typical HPV genome. HPV-56 was found in two out of every 464 normal cervical tissues, five out of every 227 cervical condylomas and CIN, and two out of every 84 invasive cervical malignancies. HPV types 16, 18, 31, 33, 34, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68, and 70 are high-risk. Some HPV varieties that are less commonly identified in malignancies but are regularly seen in squamous intraepithelial lesions are included in the high-risk group. More than 30 different kinds of human papillomavirus (HPV) infect the vaginal region. There is a well-established link between certain oncogenic (high-risk) HPV strains and cervical cancer. Although HPV is required for cervical epithelial cell transformation, it is not sufficient, and a number of cofactors and molecular processes have a role in whether cervical cancer devel
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Can Eating Burnt Foods Causes Cancer?

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  Overcooking items including toast, roast potatoes, chips, and vegetables, according to health experts, can cause cancer . According to the Food Standards Agency, starchy foods cooked at high temperatures for too long produce acrylamide, a carcinogenic chemical. When starchy foods are cooked at high temperatures, a chemical substance called acrylamide forms. A chemical interaction between specific carbohydrates and an amino acid (asparagine) in the diet causes it to develop. When muscle meat, such as beef, pig, fish, or chicken, is cooked at high temperatures, such as pan frying or grilling directly over an open flame, compounds called heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs) are generated. HCAs and PAHs have been discovered to be mutagenic in laboratory trials, meaning they create changes in DNA that may raise the risk of cancer. When amino acids, carbohydrates, and creatine or creatinine (muscle-derived compounds) react at high temperatures, HCAs
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