Is HPV 56 associated with a high risk of Cancer?

 

HPV 56 is a human papilloma from hybridization and partial nucleotide sequence analysis, the structure of HPV-56's open reading frames was determined, revealing a typical HPV genome. HPV-56 was found in two out of every 464 normal cervical tissues, five out of every 227 cervical condylomas and CIN, and two out of every 84 invasive cervical malignancies.

HPV types 16, 18, 31, 33, 34, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68, and 70 are high-risk. Some HPV varieties that are less commonly identified in malignancies but are regularly seen in squamous intraepithelial lesions are included in the high-risk group.

More than 30 different kinds of human papillomavirus (HPV) infect the vaginal region. There is a well-established link between certain oncogenic (high-risk) HPV strains and cervical cancer. Although HPV is required for cervical epithelial cell transformation, it is not sufficient, and a number of cofactors and molecular processes have a role in whether cervical cancer develops. Cervical cancer can be avoided if precancerous lesions are detected and treated early. Precancerous lesions have been identified predominantly by cytologic screening of cervical cells. Cellular abnormalities, on the other hand, may be overlooked or not differentiated enough, and a subset of individuals with borderline or weakly dyskaryotic cytomorphology will have higher-grade illness discovered by colposcopy and biopsy.

As an adjunct to cytology, sensitive and precise molecular methods that detect HPV DNA and discriminate high-risk HPV types from low-risk HPV types have been established. Early diagnosis of high-risk HPV types may enhance infected patients' triage, treatment, and follow-up. HPV DNA testing currently has the clearest function in improving diagnosis accuracy and reducing needless colposcopy in individuals with borderline or moderately abnormal cytologic test findings.

Cervical cancer is the third most frequent cancer among women in the United States, with skin cancer and breast cancer coming in first and second, respectively. Cervical cancer is the most frequent cancer among women in underdeveloped nations, accounting for up to 25% of all female cancers. Cervical cancer is the second most prevalent cause of cancer mortality in women globally, after only breast cancer.

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